A totally solvent free system for the synthesis of layered polymer crystals is also described. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. The ease of crystal structure determination today has resulted in the availability of large numbers of crystal structures of higherenergy polymorphs and pseudopolymorphs. Desiraju solid state and structural chemistry unit indian institute of science. Download civil engineering series of textbooks in the new century.
By focusing on the molecular recognition events during nucleation and growth, chemists have uncovered new ways of controlling the internal structure and symmetry of crystals and of producing materials with. Etter identifies the hydrogen bond as an important design element in crystal construction. Both are influenced by geometric and chemical considerations. May 01, 2000 semantic scholar profile for gautam r. There are around 250 research groups in crystal engineering worldwide today. Zaworotkoa received in columbia, mo, usa 25th january 2005, accepted 18th july 2005. Why design crystal structures of organic molecules. Desiraju, with 169 highly influential citations and 307 scientific research papers. Just one year later, almost as if in response, gautam desirajus book titled crystal engineering. To a crystallographer, it is crystal design based on hydrogen bonds and intermolecular interactions.
Prior to this, he had been in the university of hyderabad for 30 years. By focusing on the molecular recognition events during nucleation and growth, chemists have uncovered new ways of controlling the internal structure and symmetry of crystals and of producing materials. Vittal,arunachalam ramanan 9789814338752 published on 2011 by world scientific. It is a measure of the changing scope and meaning of the terms crystal. Modern crystal engineering has emerged as a rich discipline whose success requires an iterative process of synthesis, crystallography, crystal structure analysis, and computational methods. Click to increase image sizeclick to decrease image size free first page. Innovation in crystal engineering dariobraga,a gautamr. Crystal engineering of active pharmaceutical ingredients to improve solubility and. Over the last few years, basically during the period of existence of iucrj, there has been a huge increase in the growth and impact of this subject with ever increasing applications and products that are likely to improve the quality of life for society at large.
The subject may be approached from several directions. Desiraju in 1989, is the understanding of intermolecular interactions in the context of crystal packing and the utilization of such understanding in the design of new solids with desired physical and chemical properties. Crystal engineering can be regarded as the highly ordered and complicated supramolecular synthesis of functional crystalline solids by control of intermolecular interactions. To include a comma in your tag, surround the tag with double quotes. Editorial open access drugdrug cocrystals bhupinder singh sekhon editorial active pharmaceutical ingredients apis are most conveniently developed and delivered orally as solid dosage forms that contain a defined crystalline form of an api. Request pdf on jan 1, 2011, g r desiraju and others published crystal engineering.
Conspectusthe halogen bond is an attractive interaction in which an electrophilic halogen atom approaches a negatively polarized species. Crystal engineering has considerable overlap with supramolecular chemistry, xray crystallography, materials science, and solidstate chemistry and yet it is a distinct discipline in itself. The subject is also featured regularly in prominent chemistry journals. Desiraju in 1989, is the understanding of intermolecular interactions in the context of crystal packing and the utilization of such understanding in the design of new. Oct 10, 2014 the relevance of electron diffraction, powder methods and the use of synchrotrons and electron lasers will undoubtedly increase in all aspects of chemical crystallography. Crystal engineering is target oriented and property directed synthesis of molecular crystals. The possibility of designing a particular crystal packing is, however, of more recent origin and the subject of crystal engineering has addressed this. Crystal engineering of the composition of pharmaceutical phases.
Pdf crystal engineering in the desiraju research group. Desiraju challenges the use of cocrystal and favours the term molecular complex to describe multicomponent. Chemical crystallography and crystal engineering in india crystal engineering, as defined by g. Sep 18, 2015 read books nuclear chemical engineering mcgrawhill series in nuclear engineering ebook textbooks.
Crystal engineering of handtwisted helical crystals. In his preface to this book, professor desiraju notes the lack of interaction between the three groups of workers at. A textbook find, read and cite all the research you need on researchgate. The atomatom potential method and the closepacking model for molecular. The subject has been researched for around 40 years but there is still no textbook at the level of senior undergraduates and beginning phd students. Nov 01, 2018 crystal engineering is concerned with molecular crystals and their systematic design.
This book is important because it is the first textbook in an area that has become very popular in recent times. In 1989, desirajus 2 book on crystal engineering highlighted this issue and pointed out that although organic crystal structures are predominantly governed by kitaigorodskiis closepacking principle, the minor deviations from close packing, which result from chemical factors, are of the greatest importance because they lead to. Short halogen atom contacts in crystals have been known for around 50 years. Crystal engineering has considerable overlap with supramolecular chemistry, x. May 29, 2014 conspectusthe halogen bond is an attractive interaction in which an electrophilic halogen atom approaches a negatively polarized species. Desiraju, 1989 it is the design of organic and metalorganic solids. Bibliography includes bibliographical references and index. Mar 29, 2002 modern crystal engineering has emerged as a rich discipline whose success requires an iterative process of synthesis, crystallography, crystal structure analysis, and computational methods. It is a measure of the changing scope and meaning of the terms crystal, crystallography and crystallographer that the iucr has selected the theme of chemistry and crystal engineering as one of the areas to be covered by its flagship journal. The crystal as a supramolecular entity perspectives in supramolecular chemistry by gautam r.
The subject goes beyond the traditional divisions of organic, inorganic, and physical chemistry, and this makes for a very eclectic blend of ideas and. Crystal engineering is concerned with molecular crystals and their systematic design. How does a molecular crystal nucleate and then grow. A subject like crystal engineering has its own specialty journals including those from the union. Crystal structure prediction is of considerable fundamental and applied importance, and its successful execution is by no means a solved problem. Hydrogen bonds, coordination bonds, and other less directed interactions. As one of the most important organic solids for crystal engineering, organic optoelectronic materials have received tremendous interest in the past several decades. Crystal engineering of the composition of pharmaceutical. Crystal engineering now encompasses many aspects of solidstate. Desiraju, crystal engineeringthe design of organic solids. Chemical crystallography and crystal engineering in india. Crystal engineering of active pharmaceutical ingredients. Crystal engineering has grown over time, with its practitioners now seeking specific answers to specialized questions.
Pdf crystal engineering in the desiraju research group in. The supramolecular synthon idea in crystal engineering became a necessary and convenient method ensuring generality and predictability 75. Desiraju, 9789814338752, available at book depository with free delivery worldwide. There has however been much debate about the use of the term co crystal. He has coauthored a textbook in crystal engineering 2011. Crystal engineering is the design and synthesis of molecular solid state structures with desired properties, based on an understanding and use of intermolecular interactions.
To an organic chemist, it is supramolecular retrosynthesis with the synthon approach. The journal actively seeks papers in crystal engineering that are directed to the chemist. Dunitz terms the crystal as a supramolecule par excellence in his paper. Department of chemistry, university of bologna italy. Download free ebook of crystal engineering in pdf format or read online by gautam r.
The design of organic solids is published signifying the beginning of modern organic crystal engineering. Request pdf on jan 1, 2011, g r desiraju and others published crystal. There has however been much debate about the use of the term cocrystal. He has played a major role in the development and growth of the subject of crystal engineering. Desiraju is a structural chemist who has been in the solid state and structural chemistry unit of the indian institute of science, bangalore, india since 2009. Crystal engineering of pharmaceutical cocrystals from. The relevance of electron diffraction, powder methods and the use of synchrotrons and electron lasers will undoubtedly increase in all aspects of chemical crystallography. Crystal engineering the problem the behaviour of a functional group in a molecule during crystallization depends on the nature and positioning. The proportion of nonionic, metal free, organic compounds that crystallise as. Desiraju challenges the use of co crystal and favours the term molecular complex to describe multicomponent.
These metrics are regularly updated to reflect usage leading up to the last few days. From molecules to materials desiraju, gautam r 20030801 00. The two main strategies currently in use for crystal engineering are based on hydrogen bonding and coordination bonding. A textbook wraps up in a single book the basics of almost three decades of interdisciplinary research across the. The crystal as a supramolecular entity by gautam r. Cocrystal is a crystalline entity formed by two different or more molecular entities where the. Crystal engineering of organic optoelectronic materials. Read books nuclear chemical engineering mcgrawhill series in nuclear engineering ebook textbooks. Gautam radhakrishna desiraju is an indian chemist and educationist who has contributed substantially to the themes of crystal engineering and weak hydrogen bonding. Insights into local conformation and hydrogenbonding were derived from advanced multinuclear solidstate nmr techniques, where. Desiraju in 1989 as the understanding of intermolecular interactions in the context of crystal packing and in the utilisation of such understanding in the design of new solids with desired physical and chemical properties. Arunachalam ramanan this book is important because it is the first textbook in an area that has become very popular in recent times. Crystal engineering in the desiraju research group in bangalore. State structure and dynamics to crystal engineering.
Hn heterosynthon for synthesis of a pharmaceutical cocrystal comprised of a commonly used tablet excipient methyl paraben and quinidine, an antimalarial constituent of cinchona tree bark, has been successfully demonstrated. Gautam r desiraju is an indian chemist who has contributed substantially to the themes of crystal engineering and weak hydrogen bonding. A broad and more meaningful definition of crystal engineering was provided by g. The length, its modest price, its fair and balanced treatment of topics, and its breadth and style make it perfectly suited to serve as a onesemester course to introduce crystal engineering to undergraduate or firstyear graduate students in chemistry or materials science. Polymer structure control based on crystal engineering for. Crystal engineering of pharmaceutical cocrystals from polymorphic active pharmaceutical ingredientspeddy vishweshwar,a jennifer a. Polymer structure control based on crystal engineering for materials design. Jan 01, 2016 crystal engineering has grown over time, with its practitioners now seeking specific answers to specialized questions.
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